Food fraud in insecure times: challenges and opportunities for reducing food fraud in Africa

Food fraud describes deceptive acts that occur at all stages of the food supply chain for economic gain. The COVID-19 pandemic has had devasting impacts on individuals, institutions, and economies. Disruptions in supply chains and regulatory oversight have led to concerns about potential increases in food fraud-related incidents. In addition, the pandemic further exacerbated the issue of widespread and severe food insecurity in Africa, providing optimal conditions for fraudulent agents in the supply chain to perpetrate fraud. However, little is known about how food fraud manifests on the continent. This review explores food fraud in the African context, emphasising the impact of COVID-19. The study provides examples of food fraud and challenges of critical stakeholders in the supply chain, including consumers, industry, and regulators in combating food fraud. It also discusses recommendations for researchers and policymakers to reduce fraud and improve the quality and safety of food along the supply chain. Key Findings and Conclusions: There is consensus that the pandemic has created an environment that makes consumers more vulnerable to food fraud. However, there are significant data gaps on the incidence of food fraud, making statistical comparisons difficult. The monitoring of food fraud incidents, especially in Africa, remains in its early stages, limiting food fraud prevention efforts. Improved data collection and significant investments in testing infrastructure and technical know-how are required for developing evidence-based action plans to combat fraud at both national and intra-continent levels to safeguard consumer health.

Bioactive compounds by microalgae and potentials for the management of some human disease conditions.

Microalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-culture systems. Some of these bioactive compounds (such as polysaccharides, phycobiliproteins and lipids) are produced during their active growth phase. They appear to have antibacterial, antifungal, antiviral, antioxidative, anticancer, neuroprotective and chemo-preventive activities. These properties confer on microalgae the potential for use in the treatment and/or management of several neurologic and cell dysfunction-related disease conditions, including Alzheimer's disease (AD), AIDS and COVID-19, as shown in this review. Although several health benefits have been highlighted, there appears to be a consensus in the literature that the field of microalgae is still fledgling, and more research needs to be carried out to ascertain the mechanisms of action that underpin the effectiveness of microalgal compounds. In this review, two biosynthetic pathways were modeled to help elucidate the mode of action of the bioactive compounds from microalgae and their products. These are carotenoid and phycobilin proteins biosynthetic pathways. The education of the public on the importance of microalgae backed with empirical scientific evidence will go a long way to ensure that the benefits from research investigations are quickly rolled out. The potential application of these microalgae to some human disease conditions was highlighted.

Impact of COVID-19 on foodborne illness in Africa - A perspective piece.

Food safety investments in Africa, through international donors or national programs, were primarily focused on the formal market sector. However, increasing consumer food safety concerns about foods sold in the growing informal food markets, the rising foodborne disease burden in Africa, and the emergence of COVID-19 have all made food safety a major concern and ultimately brought it to an inflection point in Africa. In addition, Data on foodborne disease outbreaks revealed a scarcity of reported cases before and during the pandemic. The lack of information on foodborne disease reporting in Africa translates into one of the reasons why food safety in Africa is becoming a rising subject matter. This perspective discusses the situation of food safety in Africa before and after the COVID-19 pandemic. Finally, challenges confronting ongoing efforts to improve food safety in the post-COVID era in Africa are summarized and highlighted.

Yellow fever outbreak in Kenya: A review.

Yellow fever (YF) is a viral acute hemorrhagic illness caused by infected mosquitoes of the flavivirus family. The first yellow fever outbreak in Kenya was in 1992. Similar outbreaks were recorded in the western part of the country in 1993, 1995, and 2011, particularly in the Rift Valley province of Kenya. In early 2022, the viral acute illness resurfaced and hit Kenya. On January 12, 2022, the first case was discovered, with over 14 patients suffering from fever, jaundice, and joint and muscle pains. On March 4, 2022, a yellow fever outbreak re-emerged in Kenya, affecting 11 wards in Isiolo County. The fatality rate recorded was 11.3% (six deaths), with Chari accounting for 39.6% of the total 21 cases, Cherab 14 (26.4%), and 5 Garba Tulla (9.4%). This has the potential to further endanger the nation's economic growth while also negatively impacting people's daily lives in a part of the world that is already dealing with the catastrophic impacts of the coronavirus pandemic. However, there is no curative therapy for yellow fever. The only options for curbing its spread are through vaccination and preventive measures. Hence, Kenya's government must take responsibility for requiring vaccination of its citizens, implement an active national disease surveillance protocol, and set up anti-yellow fever campaigns in the country.

Bioinformatics Designing and Molecular Modelling of a Universal mRNA Vaccine for SARS-CoV-2 Infection.

At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine for different variants of SARS-CoV-2 is a study worthy of consideration. This research used bioinformatics tools to design an mRNA vaccine that captures all the circulating variants and lineages of the virus in its construct. Sequences of these viruses were retrieved across the six continents and analyzed using different tools to screen for the preferable CD8+ T lymphocytes (CTL), CD4+ T lymphocytes (HTL), and B-cell epitopes. These epitopes were used to design the vaccine. In addition, several other co-translational residues were added to the construct of an mRNA vaccine whose molecular weight is 285.29686 kDa with an estimated pI of 9.2 and has no cross affinity with the human genome with an estimated over 68% to cover the world population. It is relatively stable, with minimal deformability in its interaction with the human innate immune receptor, which includes TLR 3 and TLR 9. The overall result has proven that the designed candidate vaccine is capable of modulating cell-mediated immune responses by activating the actions of CD4+ T cells, natural killer cells, and macrophages, and displayed an increased memory T cell and B cell activities, which may further be validated via in vivo and in vitro techniques.

Food insecurity and outcomes during COVID-19 pandemic in sub-Saharan Africa (SSA).

The outbreak of COVID-19 led to the implementation of lockdowns and social distancing regulations to curb the spread of infections. Consequently, the lockdowns impeded the movement of smallholder farmers, agricultural inputs, and food products thereby disrupting the food supply chains in SSA. Therefore, this paper examines the relationship between food security indicators (accessibility, availability, utilization, stability) and COVID-19. This study uses ordinary least square regression (OLS) models to study the relationship between the food security indicators and COVID-19. The study considers 9 out of 48 sub-Saharan African countries (Benin, Burkina Faso, Cameroon, Chad, Madagascar, Mali, Mauritania, Nigeria, Senegal) due to data availability restrictions. The result of the analysis indicated that a rise in COVID-19 levels negatively impacts all the 4 indicators of food security without exception. This paper underscores the need to consider the disruptions of food security indicators such as diet, nutritional content, access and availability, affordability, and food supply chains. Moreover, the paper discusses mitigating strategies that may alleviate SSA's food security amidst the COVID-19 pandemic. We recommend that SSA countries invest in quality agricultural and food production infrastructure and supporting industries that contribute directly to the food supply chain, such as agro-processing, fertilizer production and transport. Another important dimension of the COVID-19 and food insecurity syndemic is the income shocks that occurred as a consequence of the COVID-19 outbreak. Like many factories, companies, and service providers closed shop (especially the informal sector), people lost their incomes as a result of loss of employment and, in many instances, no social protection. Therefore, we recommend that SSA governments develop affordable, sustainable, and targeted social protection/insurance systems that extend to the informal sector of the economy.

COVID-19 vaccination in Africa: A case of unsatisfied expectation and ill-preparedness.

With a population of 1.3 billion people, of which 56% reside in rural settings, Africa seemed ill-prepared to handle the distribution of a COVID-19 vaccine. In addition, the capacity needed for a successful COVID-19 vaccination campaign in Africa surpassed the available resources in local and state health agencies. As a result, African governments were advised to coordinate resources, health officials, and vaccinators, including local health practitioners, medical technicians, and pharmacists for the largest-ever vaccination campaign in Africa. Although the rolling out of the SARS-COV-2 vaccine was, as expected, slow in many African countries, and not yet enough to cover the entire population in Africa, the mass vaccination campaign in Africa must continue to ensure that priority for vaccination is extended beyond front-liners (healthcare workers) and specific high-risk populations, which has largely been the case in some African countries. This article highlights the overarching areas that we believe need to be prioritized to enhance Africa's effectiveness and coverage in the mass COVID-19 vaccination program.

Current Context of Pneumonia Amidst the COVID-19 Pandemic in Africa

Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic, several countries have been strongly affected by the different impacts of the disease. This has not been different in Africa, where in addition to the current load of COVID-19, there are other epidemics (such as pneumonia) that have aggravated the situation. In this perspective article, we discuss various aspects of pneumonia amidst the COVID-19 pandemic in Africa, including its burden, current status and efforts, and related challenges.

A short communication of Nipah virus outbreak in India: An urgent rising concern.

In the past two decades, countries like Malaysia, Singapore, Bangladesh, and India have recorded several cases of Nipah virus (NiV) infection. Following the 2018 NiV outbreak in the Kozhikode district of Kerala, India that claimed 17 lives, there has been a recent re-emergence of the virus in the same district, causing the recently reported death of a 12-year-old boy. Accordingly, population panic has heightened as inhabitants of these areas try to together combat the existing COVID-19 pandemic alongside the emerging NiV infection. Although the rate of transmission of NiV is low as compared to coronavirus disease 2019 (COVID-19), scientists suggest a higher mortality rate from NiV infection. In this manuscript, we aim to discuss the NiV infection in India as well as suggest recommendations to contain and ameliorate the severe impact of the virus on affected populations.

Anthrax outbreak amidst the COVID-19 pandemic in Africa: Challenges and possible solutions.

Anthrax and coronavirus disease 2019 (COVID-19) are both notable zoonoses that have high morbidity and mortality, not to mention adverse socio-economic and health consequences on the communities they ravage. Anthrax wreaks disease amongst mammalian species worldwide and has an endemic distribution in Africa and Asia. Kenya, for example, records an average of 10 outbreaks annually. In 2014 and 2017, it held anthrax attack rates of 15% and 29%, respectively, and case fatality rates of 1-5%. As with COVID-19, effective surveillance, containment, and vaccination programs are crucial in the fight against anthrax. While there is no evidence of direct, human-to-human transmission of anthrax currently, Bacillus anthracis remains a disease of public health concern that serves to fuel the devastating effects of SARS-CoV-2 in African communities. In this commentary, we examine anthrax spread in Africa amidst COVID-19, the challenges faced by these simultaneous zoonoses, and the efforts put to combat both equally.

Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease.

Chagas Disease (CD) is an infectious, neglected tropical disease (NTD) that has affected over 1.7 billion people worldwide. Unfortunately, most countries usually put little effort into mitigating the spread of NTDs, having weak public health approaches, diagnostic delays, and ineffective clinical management guidelines and resources. However, the ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, exacerbates the impact of NTDs. In this review, we examine the subsequent changes that have been imposed on CD prevention and treatment. Articles from Google Scholar and PubMed were extracted which satisfied our inclusion criteria. From our data, we gather that COVID-19 has - from preventive measures to treating patients - greatly affected every stage in the fight against CD. For instance, co-infection of CD and COVID-19 puts patients at higher risk for cardiomyopathy (i.e., atrial fibrillation, chronic heart failure), yet no clinical guidelines were established for co-infected patients. To mitigate the spread of CD during the COVID-19 pandemic, further investigations on the impacts of co-infections and vaccines that can be developed to treat such conditions are warranted.

The impact of COVID-19 on patients with neurological disorders and their access to healthcare in Africa: A review of the literature.

INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has hampered the progress of neurological healthcare services for patients across Africa. Before the pandemic, access to these services was already limited due to elevated treatment costs among uninsured individuals, shortage of medicines, equipment, and qualified personnel, immense distance between residing areas and neurological facilities, and a limited understanding of neurological diseases and their presentation by both the health workers and the African population. METHODOLOGY: The databases PubMed, Google Scholar, Science Direct, and the National Library of Medicine were searched for literature. All articles on neurological disorders in Africa were considered. AIM: This review article explores the challenges of providing the best services for patients suffering from neurological disorders in Africa amid the COVID-19 pandemic and provides evidence-based recommendations. RESULTS: As Africa's governments made more resources available to support patients affected by COVID-19, neurological care received less priority and the capacity and competency to treat patients with neurological disorders thus suffered substantially. Both short-term and long-term strategies are needed to improve the quality of neurological services after the pandemic in the region. CONCLUSION: To strengthen Africa's neurological services capability during and after the COVID-19 pandemic, African governments must ensure appropriate healthcare resource allocation, perform neurology management training, and increase health security measures in medication supply. Long-term strategies include incorporating responsible finance and resource procurement and advancement of tele-neurology. International collaboration is essential to promote the sustainable improvement of neurological services in Africa.

Marburg virus outbreak in Ghana: An impending crisis.

Since the initial identification of the Marburg virus in 1967, it has sporadically emerged in several countries throughout Africa, including Zimbabwe, Kenya, South Africa, the Democratic Republic of the Congo (DRC), Uganda, and Zimbabwe. Due to the concurrent occurrence of other epidemics like the coronavirus disease 2019 (COVID-19), this outbreak could endanger the healthcare systems in these many African nations. Recently, two cases of the Marburg virus were detected in Ghana for the first time. However, there has been a noticeable lack of information concerning this recent outbreak of July 2022 in Ghana. Therefore, this article seeks to provide an overview of this outbreak in Ghana to better understand the most recent status and current efforts being made to mitigate the dissemination of the Marburg virus. We also suggest recommendations that may contribute to limiting the burden of this virus.

Leishmaniasis control in the light of the COVID-19 pandemic in Africa.

Leishmaniasis is a parasitic disease, endemic to Africa, Asia, and South America due to inadequate access to medication and underreporting of leishmaniasis cases. Leishmaniasis has two forms: cutaneous and visceral. The fight against leishmaniasis has been greatly affected by the coronavirus disease 2019 (COVID-19) pandemic that impacted resource distribution and access to medication. Continuous effort in vaccine development and affordable therapeutics are necessary to eliminate leishmaniasis in low-income countries. Further research is necessary to determine molecular drug resistance markers in leishmaniasis patients. In this analysis, we focus on the effect of COVID-19 on leishmaniasis in Africa.

The impact of socio-economic indicators on COVID-19: an empirical multivariate analysis of sub-Saharan African countries.

The COVID-19 pandemic has triggered an unprecedented social and economic crisis. This study aims at investigating the impact of socio-economic indicators on the levels of COVID-19 (confirmed and death cases) in sub-Saharan Africa. The investigation makes use of the readily accessible public data: we obtain COVID-19 data from Johns Hopkins and socio-economic indicators from the World Bank. The socio-economic indicators (independent variables) used in the multilinear regression were GDP per capita, gross national income per capita, life expectancy, population density (people per sq. km of land area), the population aged 65 and above, current health expenditure per capita and total population. The dependent variables used were the COVID-19 confirmed and death cases. Amongst the seven socio-economic indicators, only 4 showed a statistically significant impact on COVID-19 cases: population density, gross national income per capita, population aged 65 and above and total population. The obtained R 2 of 69% and 63% indicated that the socio-economic indicators captured and explained the variation of COVID-19 confirmed cases and COVID-19 death cases, respectively. The startling results obtained in this study were the negative but statistically significant relationship between COVID-19 deaths and population density and the positive and statistically significant relationship between gross national income per capita and COVID-19 cases (both confirmed and deaths). Both these results are at odds with literature investigating these indicators in Europe, China, India and the UK.

The use of Ivermectin for the treatment of COVID-19: Panacea or enigma?

The outbreak of SARS-CoV-2 pandemic has triggered unprecedented social, economic and health challenges. To control and reduce the infection rate, countries employed non-pharmaceutical measures such as social distancing, isolation, quarantine, and the use of masks, hand and surface sanitisation. Since 2021 a global race for COVID-19 vaccination ensued, mainly due to a lack of equitable vaccine production and distribution. To date, no treatments have been demonstrated to cure COVID-19. The scientific World is now considering the potential use of Ivermectin as a prophylactic and treatment for COVID-19. Against this background, the objective of this study is to review the literature to demystify the enigma or panacea in the use of Ivermectin. This paper intends to investigate literature which supports the existence or shows the nonexistence of a causal link between Ivermectin, COVID-19 mortality and recovery. There are inconsistent results on the effectiveness of Ivermectin in the treatment of COVID-19 patients. Some studies have asserted that in a bid to slow down the transmission of COVID-19, ivermectin can be used to inhibit the in vitro replication of SARS-CoV-2. The pre-existing health system burdens can be alleviated as patients treated prophylactically would reduce hospital admissions and stem the spread of COVID-19. On a global scale, Ivermectin is currently used by about 28% of the world's population, and its adoption is presently about 44% of countries. However, the full administration of this drug would require further tests to establish its clinical effectiveness and efficacy.

The burden of monkeypox virus amidst the Covid-19 pandemic in Africa: A double battle for Africa.

The Coronavirus Disease - 19 (COVID-19) pandemic has put additional strain on Africa's fragile healthcare systems and has impacted the rise of emerging and re-emerging infectious diseases. Currently, there is a rise in cases of Monkeypox Disease, a zoonotic viral disease caused by the Monkeypox virus, which was first documented in 1970 in the Democratic Republic of the Congo. Most of the clinical symptoms of Monkeypox resemble that of smallpox, whose virus also belongs to the same genus. Initial symptoms include headache, fever, and fatigue, followed by lymphadenopathy and a rash. This study aims to provide more insight into Monkeypox by exposing its current burden and efforts to combat it amidst COVID-19 in Africa. Since Monkeypox disease is re-emerging and is less contagious than COVID-19, prevention and treatment are much more manageable. Still, African countries face several crucial challenges in responding to the Monkeypox in times of the covid-19 pandemic. These include lack of a well-functioning surveillance system for early detection of the disease, lack of awareness and knowledge of the monkeypox disease across the general population, lack of healthcare facilities already burdened by COVID-19 cases, and shortage of trained healthcare professionals. On the other hand, one significant factor contributing to the minimized risk in Africa was the smallpox vaccination done before 1980. However, a declining cross-protective immunity is seen in those inoculated with the smallpox vaccine and the ever-increasing risk to the unvaccinated population. Thus, focusing on vaccination and disease surveillance operations and diligent monitoring, as well as cross-border collaborations with international sectors, including One Health, FOA, OIE, and WHO is critical to achieving the ultimate eradication of monkeypox in Africa.

Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulations.

This current study review provides a brief review of a natural bee product known as propolis and its relevance toward combating SARS-CoV viruses. Propolis has been utilized in medicinal products for centuries due to its excellent biological properties. These include anti-oxidant, immunomodulatory, anti-inflammatory, anti-viral, anti-fungal, and bactericidal activities. Furthermore, studies on molecular simulations show that flavonoids in propolis may reduce viral replication. While further research is needed to validate this theory, it has been observed that COVID-19 patients receiving propolis show earlier viral clearance, enhanced symptom recovery, quicker discharge from hospitals, and a reduced mortality rate relative to other patients. As a result, it appears that propolis could probably be useful in the treatment of SARS-CoV-2-infected patients. Therefore, this review sought to explore the natural properties of propolis and further evaluated past studies that investigated propolis as an alternative product for the treatment of COVID-19 symptoms. In addition, the review also highlights the possible mode of propolis action as well as molecular simulations of propolis compounds that may interact with the SARS-CoV-2 virus. The activity of propolis compounds in decreasing the impact of COVID-19-related comorbidities, the possible roles of such compounds as COVID-19 vaccine adjuvants, and the use of nutraceuticals in COVID-19 treatment, instead of pharmaceuticals, has also been discussed.

Prospect of acute hepatitis E virus outbreak in the context of the COVID-19 Pandemic in Africa: A contingency plan.

Hepatitis E virus (HEV) is the primary cause of acute viral hepatitis in Sub-Saharan Africa (SSA). It is transmitted by oral-faecal route via contaminated water or animal products, which is more pronounced in SSA, where inadequate hygiene measures, low socioeconomic situation, and frail healthcare system increase HEV susceptibility. During the coronavirus disease-19 (COVID-19), numerous initiatives concerning viral hepatitis relief in SSA are implemented. However, national programs do not support most services and are neglected when national and local attention rests on the COVID-19 pandemic. Furthermore, during the COVID-19 pandemic, hepatitis E prevention and control programs were affected in low-income countries due to economic losses. Therefore, an interdisciplinary approach should be adopted to mitigate HEV infections during COVID-19.

Ukraine - Russia crisis and its impacts on the mental health of Ukrainian young people during the COVID-19 pandemic.

The Russia-Ukraine crisis has been at the center of international talks since early 2022. This conflict, bursting after the sanitary crisis of the covid 19 pandemic, creates an atmosphere of uncertainty and instability, which negatively impacts many aspects, including mental health. Young Ukrainians have been suffering from socio-political instability for decades, and the current war, together with the Covid 19 pandemic, shatters hopes of brighter days. This commentary covers the challenges facing the younger generation in Ukraine and the impact of this situation on their mental health.